Dataset: Theory of defect-mediated morphogenesis

This archive contains the experimental and numerical data produced and analyzed for the article "Theory of defect-mediated morphogenesis". The archive is divded in two main folders: - Experimental_Data - Simulation_Data The folder "Experimental_Data" contains the row microscopy pictures of the domes taken in MDCK cells experiments a partially shown in Fig. 1(D) of the main text and in the Supplementary Informations. Each gif file shows two superimposed channels, namely E-cadherin (green) and Nucleus (blue). The stack outside the sample and move towards the monolayer. The plane-to-plane distance is 0.172 um and one pixel corresponds to 0.3451 um. The folder "Simulation_Data" contains the configurations and the raw data produced by means of numerical simulations. The content is divided in subfolders and classified according to the Figure and panels where the data are shown. Simulation parameters are reported in the main text and in the Supplementary Information of the paper "Theory of defect-mediated morphogenesis". Simulation configurations are saved as vtm files. Each vtm file contains the values at each grid points of the polarization (Px,Py,Pz) and velocity field (ux,uy,uz) as well as the concentration field (phi). Vtm files can be visualized through the open-source visualization software Paraview. In folder Simulation_Data/Fig_2_panel_H the time series of the L2 distance of the measured profile with respect to the flat interface are found. The files is organized as follows: 1st column shows the time (iteration) at which the measurement is performed, 2nd column shows the L2 distance.This work is supported by the Netherlands Organization for Scientific Research (NWO/OCW), as part of the Vidi scheme (L.A.H. and L.G.), and by the European Union via the ERC-CoGgrant HexaTissue (L.N.C. and L.G.). Part of this work was carried out on the Dutch national e-infrastructure with the support of SURF through the Grant 2021.028 for computational time (L.A.H., L.N.C and L.G.)