TO DESIGN AND DEVELOP SOLID LIPID NANOPARTICLES BASED NANOGEL FOR DERMAL DELIVERY OF MELOXICAM

Topical drug delivery can be defined as application of medication containing formulation to the skin to directly treat the cutaneous or subcutaneous disorders and diseases like acne or fungal infections by providing the drug to the surface of the skin or within the skin. In spite of many advantages of transdermal and dermal drug delivery over other drug delivery system, relatively few topical drug formulations are commercially available in market. The main challenging step in the topical delivery is the crossing of most impermeable epithelia of human body that is stratum corneum. Stratum corneum becomes a barrier for the exogenetic substances. Hence this fact is to be considered at the time of formulating a new formulation for the topical administration of drug so that maximum penetration of the drug into the skin without irreversible disturbing the skin barrier function can be achieved. KEYWORDS- Nanoparticles, Nanogel, Meloxica