Co-occurrence of the blaVIM-1 and blaSHV-12 genes on an IncHI2 plasmid of an Escherichia coli isolate recovered from German livestock

The dissemination of carbapenemase-producing Enterobacterales (CPE) is an important public health issue. The number of human CPE isolates has been steadily increasing during recent years, worldwide. Despite the fact that carbapenems are not licensed for use in veterinary medicine, increasing numbers of CPE from the veterinary sector have been reported.1 The transmission of CPE between pets/livestock and exposed humans as well as via food has been demonstrated.2 In this study, a detailed characterization of a carbapenem-resistant porcine Escherichia coli co-harbouring blaVIM-1, blaSHV-12 and blaACC-1 genes, along with other resistance genes, is provided.This work was supported by the German Federal Institute for Risk Assessment (43-001), and the German Federal Ministry of Education and Research (BMBF) under project number 01KI1727D as part of the Research Network Zoonotic Infectious Diseases