Novel Targets to Promote RGC Axon Regeneration (Park Lab) The aim of this project is to idenity genes and lipids that give subtypes of retinal ganglion cells a greate propensity to regenerate axons and form function synaptic connections. This work has been published in the following manuscripts: Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells (2019-08-21) Lipid profiling dataset of the Wnt3a-induced optic nerve regeneration (2019-05-24) Our results identify cell-type-specific induction of Thbs1 as a novel gene conferring high regenerative capacity. See the following visualizations to explore the findings: Thrombospondin-1 Mediates Axon Regeneration in RGC
The loss of retinal ganglion cells (RGCs) causes irreversible vision loss in glaucoma and optic neur...
Purpose: We investigated the involvement of matrix metalloproteinase-2 (MMP-2) in axonal regeneratio...
The loss of retinal ganglion cells (RGCs) causes irreversible vision loss in glaucoma and optic neur...
Failure of axon regeneration is a major barrier for recovery following neurological injury. Neurons ...
A major reason why central nervous system (CNS) trauma and many neurodegenerative diseases demonstra...
How adult neurons coordinate lipid metabolism to regenerate axons remains elusive. We found that dep...
Factors present in the extracellular environment are crucial to the success of nerve regeneration. O...
Molecular Discovery for Optic Nerve Regeneration (Goldberg, Benowitz and Cline labs): The aim of th...
Summary: Axonal regrowth is crucial for recovery from CNS injury but is severely restricted in adult...
Adult retinal ganglion cells (RGCs) can regenerate their axons in vitro. Using proteomics, we discov...
In adult mammals, retinal ganglion cells (RGCs) fail to regenerate following damage. As a result, RG...
Abstract Retinal Ganglion Cells (RGCs) lose their ability to grow axons during development. Adult RG...
In adult mammals, retinal ganglion cells (RGCs) fail to regenerate following damage. As a result, RG...
SummaryIn mammals, few retinal ganglion cells (RGCs) survive following axotomy, and even fewer regen...
Neuroregeneration research seeks to address why mature neurons of the central nervous system (CNS) f...
The loss of retinal ganglion cells (RGCs) causes irreversible vision loss in glaucoma and optic neur...
Purpose: We investigated the involvement of matrix metalloproteinase-2 (MMP-2) in axonal regeneratio...
The loss of retinal ganglion cells (RGCs) causes irreversible vision loss in glaucoma and optic neur...
Failure of axon regeneration is a major barrier for recovery following neurological injury. Neurons ...
A major reason why central nervous system (CNS) trauma and many neurodegenerative diseases demonstra...
How adult neurons coordinate lipid metabolism to regenerate axons remains elusive. We found that dep...
Factors present in the extracellular environment are crucial to the success of nerve regeneration. O...
Molecular Discovery for Optic Nerve Regeneration (Goldberg, Benowitz and Cline labs): The aim of th...
Summary: Axonal regrowth is crucial for recovery from CNS injury but is severely restricted in adult...
Adult retinal ganglion cells (RGCs) can regenerate their axons in vitro. Using proteomics, we discov...
In adult mammals, retinal ganglion cells (RGCs) fail to regenerate following damage. As a result, RG...
Abstract Retinal Ganglion Cells (RGCs) lose their ability to grow axons during development. Adult RG...
In adult mammals, retinal ganglion cells (RGCs) fail to regenerate following damage. As a result, RG...
SummaryIn mammals, few retinal ganglion cells (RGCs) survive following axotomy, and even fewer regen...
Neuroregeneration research seeks to address why mature neurons of the central nervous system (CNS) f...
The loss of retinal ganglion cells (RGCs) causes irreversible vision loss in glaucoma and optic neur...
Purpose: We investigated the involvement of matrix metalloproteinase-2 (MMP-2) in axonal regeneratio...
The loss of retinal ganglion cells (RGCs) causes irreversible vision loss in glaucoma and optic neur...