Fig. 1 in The metabolic sensitivity of hydrogen isotope fractionation differs between plant compounds

Fig. 1. Schematic, simplified overview of plant leaf carbohydrate, acetogenic lipid, and phytol synthesis. Reactions altered by impaired enzyme activities through mutations in the starch synthesis pathway marked in red for A. thaliana, or otherwise annotated for different species. Arrows in blue indicate putative reactions where C-bound H-exchange can occur. NADPH production is marked in purple and NADPH consumption is marked in pink. All used mutants accumulate trace amounts of starch, *except for the adg2-1 genotype, which accumulates around 40% of WT starch levels (Lin et al., 1988a). The MEP and acetogenic pathways are highlighted by yellow and orange dashed lines, respectively. Night-time starch degradation can provide a source of 2H-depleted carbohydrates in WT plants and is marked with brown dashed lines. Transport of G6P across the chloroplast membrane, indicated by the dashed black line, may occur when chloroplast G6P reach excess levels, like in pgm mutants (Kunz et al., 2010). Organic compounds extracted and measured for δ2H are shown in outlined white boxes. Abbreviations: 3PGA, 3-phosphoglycerate; Acetyl-CoA, acetyl coenzyme A; ADPGlc, ADP-glucose; CBB cycle, Calvin-Benson-Bassham cycle; DHAP, dihydroxyacetone phosphate; DOXP, 1-deoxy-D-xylulose 5-phosphate; F1,6BP, fructose 1,6-bisphosphate; F6P, fructose 6-phosphate; FA, fatty acid; Fd, ferredoxin; FNR, ferredoxin-NADP+ reductase; G6P, glucose 6-phosphate; G1P, glucose 1-phosphate; GAP, glyceraldehyde 3-phosphate; GGPP, geranylgeranyl pyrophosphate; Glc, glucose; IPP, isopentenyl pyrophosphate; Mal, maltose; MEP, 2-C-methylerythritol 4-phosphate; oxPPP, oxidative pentose phosphate pathway; Sucrose 6P, sucrose 6-phosphate; UDPGlc, UDP-glucose. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)Published as part of Baan, Jochem, Holloway-Phillips, Meisha, Nelson, Daniel B. & Kahmen, Ansgar, 2023, The metabolic sensitivity of hydrogen isotope fractionation differs between plant compounds, pp. 1-11 in Phytochemistry (113563) 207 on page 2, DOI: 10.1016/j.phytochem.2022.113563, http://zenodo.org/record/829059