FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF FAMOTIDINE

In the present research work an attempt was made to design formulation and evaluation of gastroretentive floating tablets of famotidine. Quantitative estimation of famotidine in formulation was carried out by UV/Visible spectrophotometry using 0.1 N HCl (pH-1.2) as solvent and measuring the absorbance at 266 nm. Compatibility studies of drug with excipients were performed under different storage condition for one month. For immediate release layer, it was found that all the batches gives release of more than 85 % of drug with in 30 minutes due to the high solubility of famotidine. Povidone is selected for the immediate release disintegrating agent for the reason that its was used in low quantity with less disintegration time (second) and having required physical properties i.e. Hardness, Friability, etc. For sustained release second layer, the use of hydrophilic polymer matrix is one of the most popular approaches in formulating an extended-release dosage form. Hydroxypropyl Methyl Cellulose (HPMC) has been widely used due to its rapid hydration, good compression and gelling characteristic, its ease of use, availability and very low toxicity. The famotidine release from the floating tablet was found to be 87.37 to 94.83 % with methocel k 100 M. The release profile of drug was observed and it was found that when the lactose was used at a concentration of 20 mg per tablet the release upto 89.37 % was observed and as the concentration of channeling agent i.e. lactose increases there is increase in the release was observed. Keywords: Gastric emptying, absorption, bioavailability, sustained release, controlled releas