ROBERTSONIAN TRANSLOCATION PATIENT WITH RECURRENT MISCARRIAGE

Translocation is a type of chromosomal abnormality, which results in a chromosome breaks where the portion of it reattaches to a different chromosome. This includes balanced and unbalanced translocation, with two main types: reciprocal -and Robertsonian translocation. Robertsonian translocation is a type of translocation caused by breaks at or near the centromeres of two acrocentric chromosomes. The reciprocal exchange of parts gives rise to one large metacentric chromosome and one extremely small chromosome that may be lost from the organism with little effect because it contains few genes. The resulting karyotype in humans leaves only 45 chromosomes, since two chromosomes have fused together. Robertsonian translocation is one of the major chromosomal rearrangements with a prevalence rate of 0.1% of the general population and 1% of the infertile population. These chromosomal translocations are mainly observed in group D including 13, 14, 15 and group G including 21 and 22 chromosome