MELAMINE TRISULFONIC ACID (MTSA) ON NEUTRAL ALUMINA CATALYZED AZA-MICHAEL ADDITION OF ALIPHATIC AMINES TO α, β - UNSATURATED CARBONYL COMPOUNDS AND NITRILES

Melamine Trisulfonic Acid (MTSA) on Neutral Alumina is used as an efficient catalyst for aza-Michael addition of primary and secondary aliphatic amines to a series of α,β-unsaturated carbonyl compounds and nitriles in acetonitrile to produce the corresponding β-amino derivatives in high yields. The method being simple and offers chemoselectivity, as aromatic amines were found to be unreactive