Data from: Mouse screen reveals multiple new genes underlying mouse and human hearing loss
- Ingham, Neil J.
- Pearson, Selina A.
- Vancollie, Valerie E.
- Rook, Victoria
- Lewis, Morag A.
- Chen, Jing
- Buniello, Annalisa
- Martelletti, Elisa
- Preite, Lorenzo
- Lam, Chi C.
- Weiss, Felix D.
- Powis, Zoe
- Suwannarat, Pim
- Lelliot, Christopher J.
- Dawson, Sally J.
- White, Jacqueline K.
- Steel, Karen P.
DOIAbstract
Adult-onset hearing loss is very common but we know little about the underlying molecular pathogenesis, impeding development of therapies. We took a genetic approach to identify new molecules involved in hearing loss by screening a large cohort of newly-generated mouse mutants using a sensitive electrophysiological test, the auditory brainstem response. We review here the findings from this screen. Thirty-eight unexpected genes associated with raised thresholds were detected from our unbiased sample of 1,211 genes tested, suggesting extreme genetic heterogeneity. A wide range of auditory pathophysiologies was found, and some mutant lines showed normal development followed by deterioration of responses, revealing new molecular pathways i...
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