Synthesis of Some New 2,4,6-Triaryl Substituted Pyridines via Pyridinium Ylides

Department of Chemistry, H. B. Technological Institute, Kanpur-208 002 Manuscript received 12 April 1979, revised 14 March 1980, accepted 28 January 1981 Reactions of 4-methoxy phenacyl pyridinium ylide and 4-chlorophenacyl pyridinium ylide with different substituted α-\(\beta\) unsaturated ketones gave a wide variety of 2,4,6- triaryl substituted pyridines which are expected to possess marked biological activities. The reaction presumably proceeds via formation of 1,5-dionyl pyridinium intermediate (4a-n). Ammonium acetate in acetic acid was used as cyclization agent. The structures of the products were confirmed either by nmr or by ir spectrum analysis