A simple, rapid, and selective quantitative nuclear magnetic resonance spectroscopic method was evaluated for the determination of the content of fluorinated pharmaceuticals. 19F NMR spectra were either obtained in dimethylsulfoxide-d6 or aqueous buffer, using trifluoroacetic acid as internal standard. Quantification of 13 fluorine-containing pharmaceuticals spanning various pharmacological classes was accomplished using the proposed method. The method was found to be fit for purpose (interday precision 1.2% relative standard deviation) and may thus be applied for routine analysis and quality control of fluorine-containing pharmaceuticals due to its simplicity, nondestructive sample measurement, reliability, and high specificity. Therefore,...
Fluorine NMR spectroscopy is widely used for detection of protein-ligand interactions in drug discov...
The 19F{1H} saturation transfer difference (STD) method was improved for sensitive 19F detection usi...
The fluorine nucleus, when introduced as a reporter group in membrane-associated proteins or peptide...
Nuclear Magnetic Resonance (NMR) is a technique with several advantages, such as high rapidity and e...
International audiencePurity assessment of organometallics is particularly important for catalytic a...
The article describes a newly developed procedure of quantitative determination of fluorine which is...
Fragment screening performed with 19F NMR spectroscopy is becoming increasingly popular in drug dis...
These preliminary studies of dynamic natural abundance 19F-magnetic resonance spectroscopy (19F-MRS)...
Two distinct fluorine-19 nuclear magnetic resonance (19F NMR) signals have been observed in human se...
With the spectacular advancement of NMR techniques and the flourishing of fluorine chemistry allowin...
This thesis describes a study into the improvement of solid-state NMR methods for the detection and ...
International audienceA new pulse sequence for obtaining 19F detected DOSY (diffusion ordered spectr...
The combinational use of one-dimensional (1D) NMR-based screening techniques with 1H and 19F detecti...
A compact lab plant was designed for the continuous-flow synthesis of fluorine-containing compounds ...
International audienceWith the spectacular advancement of NMR techniques and the flourishing of fluo...
Fluorine NMR spectroscopy is widely used for detection of protein-ligand interactions in drug discov...
The 19F{1H} saturation transfer difference (STD) method was improved for sensitive 19F detection usi...
The fluorine nucleus, when introduced as a reporter group in membrane-associated proteins or peptide...
Nuclear Magnetic Resonance (NMR) is a technique with several advantages, such as high rapidity and e...
International audiencePurity assessment of organometallics is particularly important for catalytic a...
The article describes a newly developed procedure of quantitative determination of fluorine which is...
Fragment screening performed with 19F NMR spectroscopy is becoming increasingly popular in drug dis...
These preliminary studies of dynamic natural abundance 19F-magnetic resonance spectroscopy (19F-MRS)...
Two distinct fluorine-19 nuclear magnetic resonance (19F NMR) signals have been observed in human se...
With the spectacular advancement of NMR techniques and the flourishing of fluorine chemistry allowin...
This thesis describes a study into the improvement of solid-state NMR methods for the detection and ...
International audienceA new pulse sequence for obtaining 19F detected DOSY (diffusion ordered spectr...
The combinational use of one-dimensional (1D) NMR-based screening techniques with 1H and 19F detecti...
A compact lab plant was designed for the continuous-flow synthesis of fluorine-containing compounds ...
International audienceWith the spectacular advancement of NMR techniques and the flourishing of fluo...
Fluorine NMR spectroscopy is widely used for detection of protein-ligand interactions in drug discov...
The 19F{1H} saturation transfer difference (STD) method was improved for sensitive 19F detection usi...
The fluorine nucleus, when introduced as a reporter group in membrane-associated proteins or peptide...