IN-VITRO COMPARATIVE STUDY OF THREE DIFFERENT BRANDS OF FAMOTIDINE40 MG TABLETS AVAILABLE IN LOCAL PHARMACIES OF KARACHI

Famotidine 40 mg film coated tablet by invitro comparative study , together with the official and non official compendial test. Famotidine is an aggressive inhibitor of histamine H2-receptors. The pivotal clinically critical pharmacologic activity of Famotidine is to hold of gastric discharge. Both the acid concentration and volume of gastric secreation are concealed by famotidine, while changes in pepsin discharge are relative to volume generation. Famotidine is more potent than other class of drugs like.the drug is intended to release after oral administration for immediate release so we execute testing analysis to illustrate the procedure, the major test for analyzing the effectiveness of drug comprises, dissolution , assay, disintegration time, thickness and weight variation in three brands available in market of Karachi Pakistan. The weight variation test shows outcomes within the limits and all brands dissolves within 30 minutes, every brand showed the drug dissolution more than 75 % within the 30 minutes ,all outcome showed good effectiveness and producing outcomes within the limits and complying the USP recomendation. Key Words: Compendial test, immediate release, competitive inhibitor, famotidine, tablet