The Conformation of the Mannopyranosyl Phosphate Repeating Unit of the Capsular Polysaccharide of Neisseria meningitidis Serogroup A and Its Carba-Mimetic

The design and synthesis of novel and hydrolytically stable structural analogues of MenA CPS may provide additional tools for the development of therapies against this disease. In this context, the structural features of the natural phosphorylated monomer have been analyzed and compared to those of its carbs analogueMINECO for Grant CTQ2015-64597-C2-1P and for the Severo Ochoa Excellence Accreditation (SEV-2016-0644). We also thank MINECO (projects CTQ2015-67727-R to F. C., CTQ2015-70524-R and RYC- 2013-14706 to G. J. O.)