Progress in survival in renal cell carcinoma through 50 years evaluated in Finland and Sweden

Global survival studies have shown favorable development in renal cell carcinoma (RCC) treatment but few studies have considered extended periods or covered populations for which medical care is essentially free of charge. We analyzed RCC survival in Finland and Sweden over a 50-year period (1967-2016) using data from the NORDCAN database provided by the local cancer registries. While the health care systems are largely similar in the two countries, the economic resources have been stronger in Sweden. In addition to the standard 1- and 5-year relative survival rates, we calculated the difference between these as a measure of how well survival was maintained between years 1 and 5. Relative 1- year survival rates increased almost linearly in both countries and reached 90% in Sweden and 80% in Finland. Although 5-year survival also developed favorably the difference between 1- and 5-year survival rates did not improve in Sweden suggesting that the gains in 5-year survival were entirely due to gains in 1-year survival. In Finland there was a gain in survival between years 1 and 5, but the gain in 1-years survival was the main contributor to the favorable 5-year survival. Age group specific analysis showed large survival differences, particularly among women. Towards the end of the follow-up period the differences narrowed but the disadvantage of the old patients remained in 5-year survival. The limitations of the study were lack of information on performed treatment and clinical stage in the NORDCAN database. In conclusion, the available data suggest that earlier diagnosis and surgical treatment of RCC have been the main driver of the favorable change in survival during the past 50 years. The main challenges are to reduce the age-specific survival gaps, particularly among women, and push survival gains past year 1.European Union's Horizon 2020 research and innovation programme, grant No 856620 (Chaperon), to KH, Jane and Aatos Erkko Foundation (6-5900-29), Sigrid Juselius Foundation (63-4925-56), Finnish Cancer Organizations (6-5156-32), Biomedicum Helsinki Foundation (73604201), University of Helsinki (797011008), Helsinki University Central Hospital (TYH2019215), Novo Nordisk Foundation (0058602), Pa¨ivikki and Sakari Sohlberg Foundation (10-6623-11), all to AH. Funding agencies had no role in the study