Synthesis, deposition, and interactions of hyaluronan (HA) with its cellular receptor CD44 are crucial events that regulate the onset and progression of tumors. The intracellular signaling pathways initiated by HA interactions with CD44 leading to tumorigenic responses are complex. HA molecules may perform dual functions depending on their concentration and size. Overexpression of variant isoforms of CD44 (CD44v) is most commonly linked to cancer progression, whereas their loss is associated with inhibition of tumor growth. In this review, we highlight that regulation of HA synthases (HASes) by post-translational modifications such as O-GlcNAcylation and ubiquitination, or by environmental factors or the action of microRNAs is important for...
AbstractCD44, a major receptor for glycosaminoglycan hyaluronan (HA), is a broadly distributed cell ...
Hyaluronan (HA), a structural component in the extracellular matrix (ECM), has been recognized as a ...
Solid tumor invasion, metastasis and therapeutic drug resistance are the common causes for serious m...
Synthesis, deposition, and interactions of hyaluronan (HA) with its cellular receptor CD44 are cruci...
Hyaluronan (HA), a major component of the extracellular matrix (ECM), is enriched in many types of t...
A hallmark of all solid tumor malignancies is the ability to invade the surrounding tissue and/or me...
CD44 is a multifunctional adhesion molecule typically upregulated in malignant, inflamed and injured...
Hyaluronan is a ubiquitous glycosaminoglycan which is an important constituent of the extracellular ...
Metastasis is the leading cause of death in patients with cancer, and the extracellular matrix is cr...
Tumor malignancies involve cancer cell growth, issue invasion, metastasis and often drug resistance....
CD44 is a cell surface receptor of hyaluronate that is implicated in the regulation of tumor growth ...
Abstract CD44, a non-kinase transmembrane glycoprotein, is overexpressed in several cell types inclu...
CD44 is a polymorphic cell surface glycoprotein, currently proposed to be the principal cell surface...
CD44 is a polymorphic cell surface glycoprotein, currently proposed to be the principal cell surface...
Hyaluronan, a prevalent glycosaminoglycan of the extracellular space often accumulates in pathologic...
AbstractCD44, a major receptor for glycosaminoglycan hyaluronan (HA), is a broadly distributed cell ...
Hyaluronan (HA), a structural component in the extracellular matrix (ECM), has been recognized as a ...
Solid tumor invasion, metastasis and therapeutic drug resistance are the common causes for serious m...
Synthesis, deposition, and interactions of hyaluronan (HA) with its cellular receptor CD44 are cruci...
Hyaluronan (HA), a major component of the extracellular matrix (ECM), is enriched in many types of t...
A hallmark of all solid tumor malignancies is the ability to invade the surrounding tissue and/or me...
CD44 is a multifunctional adhesion molecule typically upregulated in malignant, inflamed and injured...
Hyaluronan is a ubiquitous glycosaminoglycan which is an important constituent of the extracellular ...
Metastasis is the leading cause of death in patients with cancer, and the extracellular matrix is cr...
Tumor malignancies involve cancer cell growth, issue invasion, metastasis and often drug resistance....
CD44 is a cell surface receptor of hyaluronate that is implicated in the regulation of tumor growth ...
Abstract CD44, a non-kinase transmembrane glycoprotein, is overexpressed in several cell types inclu...
CD44 is a polymorphic cell surface glycoprotein, currently proposed to be the principal cell surface...
CD44 is a polymorphic cell surface glycoprotein, currently proposed to be the principal cell surface...
Hyaluronan, a prevalent glycosaminoglycan of the extracellular space often accumulates in pathologic...
AbstractCD44, a major receptor for glycosaminoglycan hyaluronan (HA), is a broadly distributed cell ...
Hyaluronan (HA), a structural component in the extracellular matrix (ECM), has been recognized as a ...
Solid tumor invasion, metastasis and therapeutic drug resistance are the common causes for serious m...