Synthesis and biological activities of some quinoxaline derivatives bearing aromatic halogen nucleus

Department of Chemistry, Saurashtra University, RaJkot-360 005, India E-mail : drhsjoshi@yahoo.com Fax : 91-281-578512 Manuscript received 4 April 2002, revised 1 January 2003. accepted 21 March 2003 1-Aryl-3-(3'-chlorophenyl)-2-propen-1-ones (1a-j) on reaction with bromine in acetic acid yielded 1-aryl-3-(3'-chlorophenyl)-2,3-dibromopropan-1-ones (2a-j). Reaction of 2a-j with o-phenylenediamine afforded the corresponding 2-(3'-chlorophenyl)-3-substituted benzylquinoxaline (3a-j). The synthesized compounds were evaluated for their anticancer, antitubercular and antimicrobial activities