QUALITY CONTROL ANALYSIS AND ASSESSMENT OF DIFFERENT MARKET TABLET BRANDS OF FLURBIPROFEN

Good manufacturing practice explain the procedures as well as quality control methods for better and satisfactory result, key methods to ensure the quality control of drugs has been followed during all research to maintain the required standard .Flurbiprofen is rapidly and almost completely absorbed following oral administration and used as analgesic and anti-inflammatory drug. The half-life of the Flurbiprofen is 0.5 - 4 hours after oral administration. Seven different brands of Flurbiprofen were selected to perform their Quality test. In this study, safest and most suitable brand among other available brands in Pakistan were selected. Several methods for quality control were done such as thickness, hardness, weight variation, disintegration, dissolution were performed according to the specifications. Drug release percentages of different brands were from 99.58, 98.52, 98.25, 100.0, 99.10, 99.12, and 99.85. The Quality control tests of all the different brands of Flurbiprofen which are tested are within the limits. All Physical tests and dissolution tests were done according to the specified specifications. All the test included hardness, thickness, weight variation, disintegration and dissolution were tested and the results were within acceptable range. Key Words: Quality control, Flurbiprofen, Physical tests, Dissolution