Autoimmune / inflammatory syndrome induced by adjuvants (ASIA) – variety of symptoms

Makarewicz Magdalena, Łapa Katarzyna, Kubicka Magdalena, Maziarz Barbara, Nieradko-Iwanicka Barbara. Autoimmune / inflammatory syndrome induced by adjuvants (ASIA) – variety of symptoms. Journal of Education, Health and Sport. 2019;9(6):55-63. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3236805 http://ojs.ukw.edu.pl/index.php/johs/article/view/6971 https://pbn.nauka.gov.pl/sedno-webapp/works/914987 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.05.2019. Revised: 25.05.2019. Accepted: 01.06.2019. Autoimmune / inflammatory syndrome induced by adjuvants (ASIA) – variety of symptoms Magdalena Makarewicz https://orcid.org/0000-0003-0485-8998 m.makarewicz.97@gmail.com Katarzyna Łapa https://orcid.org/0000-0002-8339-118X katarzyna.lapa95@gmail.com Magdalena Kubicka https://orcid.org/0000-0002-1645-8943 magdalenakubickaa@wp.pl Barbara Maziarz https://orcid.org/0000-0002-8339-1187 basssmaz@gmail.com dr hab. n. med. Barbara Nieradko-Iwanicka https://orcid.org/0000-0002-4839-6003 barbaranieradkoiwanicka@umlub.pl Medical University in Lublin Chair and Department of Hygiene Al. Racławickie 1 20-059 Lublin NIP 7120106911 Abstract Introduction The autoimmune / inflammatory syndrome induced by adjuvants (ASIA) has been described by Shoenfeld and Agon-Levin (in 2011). It is an autoimmune / auto-inflammatory disease caused by adjuvants. Adjuvants are substances able to induce autoimmunity via various mechanisms such as a change in the host immune system, polyclonal activation of B cells, effects on cellular immunity, immunoregulatory cells, antibodies induced by viruses or acceleration of molecular mimicry. The aim The purpose of the work was to congregate information about ASIA useful in medical practice. State of knowledge The ASIA syndrome can be diagnosed when two main or one main and two smaller criteria are fulfil. The main criteria: External stimulus exposure Muscle pains, muscle inflammation or muscle weakness Arthralgia and / or arthritis Chronic fatigue, sleep without rest or sleep disorder Neurological symptoms Impaired cognitive function, memory loss Fever, dry mouth Removal of the inducing factor induces an improvement Result of organ biopsy Smaller criteria: Other clinical signs (irritable bowel syndrome) Presence of HLA antigens (ie HLA DRB1, HLA DQB1) Development of autoimmune disease (multiple sclerosis, systemic sclerosis). Asia syndrome may occur after implantation of silicone breast implants and cause various complications of other pain, fever and skin changes. Conclusion Autoimmune / auto-inflammatory disorders can be caused by silicone implants and vaccine adjuvants: they include the presence of autoantibodies, muscle and joint pain, lupus-like symptoms and hardened-like symptoms. Key words: ASIA; adjuvants; autoimmune syndrom