ASSOCIATION OF HAEMATOLOGICAL PARAMETERS REFERENCE VALUES VARIATION WITH VARIOUS ATTRIBUTING FACTORS

Objectives: We assessed reference Hematological parameters values variation including Total Leucocyte Count (TLC), Hemoglobin (Hb), Platelet Counts (PLT) and Red Blood Cells (RBC) in neonates and its comparison with the similar natured research international studies. Subjects and Methods: Research was descriptive in nature conducted at Services Hospital, Lahore (Department of Hematology) in the time span of six months starting from August, 2016 to January, 2017. Non-probability method of sampling was used for selection of a sample that consisted of 400 neonates. We assessed the samples of the blood by using an automated hematology analyzer (Sysmex Kx-21) for Total Leucocyte Count (TLC), Hemoglobin (Hb), Platelet Counts (PLT) and Red Blood Cells (RBC). Results: Reference values taken as (mean 7 SD) for RBC, TLC and platelets count were respectively (4.931012 / l & 0.54), (16.109 / l & 5.35) and (258.499109 / l & 70.5). These mean values were more than the values reported in the international research studies. Reference mean Hb value was low than the internationally reported values as (14g/dl & 2.5) which was reported (16.89 g/dl & 1.92) in the international research studies. As per the comparative research the mean values and SD in the international research study were observed about RBC, TLC and Platelets as (4.21012 / l & 1.2), (12.109 / l & 7) and (200109 / l & 50). Conclusions: Our hematological parameters reference values of neonates are not same as implemented in international research studies; which leads to a conclusion that numerous and different ethnic, maternal, nutritional, environmental, cultural and socioeconomic factors have an effect on the neonatal hematological parameters. Key words: Total Leucocyte Count (TLC), Hemoglobin (Hb), Platelet Counts (PLT) and Red Blood Cells (RBC), Neonates, Hematological and Parameters