ANALYSIS OF CHANGES IN THE LIVER ENZYMES IN THE PATIENTS SUFFERING FROM LIVER CIRRHOSIS

Introduction: Liver is a complex organ with interdependent metabolic, excretory and defense functions. The use of several screening tests improves the detection of hepato-biliary abnormalities, helps differentiate the basis for clinically suspected disease and determine the severity of liver disease. Objectives: The main objective of the study is to analyze the changes in the liver enzymes in the patients suffering from liver cirrhosis. Methodology of the study: This cross sectional study was conducted at RHC Khalian Bajwat, Sialkot during October 2018 to Feburary 2019. The data was collected through non-probability sampling technique. The data was collected from 100 liver cirrhosis patients. The age range for this study was 20 to 60 years. Blood sample was collected for the serum analysis of liver enzymes. Alanin aminotransferase (ALT) and Aspartate aminotransferase (AST) were assayed by Reitman and Frankel method. Results: The data was collected from 100 patients of both genders. The mean age of the patients were 45.67±3.56 years. The levels of ALT in patients was 258.2±91.73, 79.66±28.63, and 50.73± 8.4 respectively as compared to normal control (11±3.42). Aspartate aminotransferase levels were significantly raised in viral hepatitis, alcoholic liver disease and cirrhosis patients. The levels being 157.80±67.8, 164±54.35, and 62±12.17 respectively as compared to normal control (13±3.54). Conclusion: It is concluded that the level of all liver enzymes become increases in cirrhosis condition. Liver associated enzymes tests are used to detect, specifically diagnose, and estimate the severity of hepatic disease