FORMULATION, CHARACTERIZATION AND INVITRO EVALUATION OF ISONIAZID MICROSPHERES

ABSTRACT The aim of present work is to investigate the possibility of obtaining a prolonged, relatively constant effect of isoniazid microspheres by using HPMC and egg albumin as carriers. The present study was aimed to develop and evaluate microspheres of isoniazid (INH) in different drug to polymer ratios using emulsification heat stabilization method. In-vitro drug release studies were performed using the shaking flask method. FTIR studies showed that there was no chemical interaction between the drug and polymers. Scanning electron microscopy showed the microspheres having a spherical structure. Prepared microspheres were characterized for particle size, zeta potential and in-vitro drug release studies. Microspheres showed the particle size of about 70% was in size range of 178.1 nm and zeta potential found to be -49.2 mV. Formulation INH3 showed prolongs drug release. In the present study a satisfactory attempt was made to develop micro particulate drug delivery system of INH with improved bioavailability, efficient targeting and dose reduction. KEYWORDS: Microspheres, Isoniazid, Zetapotential, Particle size Analysis, Shaking flask method