THE ASSOCIATION BETWEEN SEVERE VITAMIN D DEFICIENCY AND MORTALITY IN PATIENTS WITH COVID-19

Aim: The objective of this is to determine the association between severe vitamin D deficiency and mortality in patients presented with covid-19. Study Design: Prospective/Observational Place and Duration: The study was conducted at Benazir Bhutto Hospital, Rawalpindi for duration of three months from 1st July to 30th September, 2020. Materials & Methods: In our study, total 140 patients of both genders who were diagnosed with covid-19 were enrolled. Patients ages were ranging from 15 years to 75 years. Detailed demographics including age, sex, and body mass index (BMI) were recorded after taking written consent. 5 ml blood sample was taken from all the patients to examine the vitamin D level. Severe Vitamin D deficiency was defined as 25(OH)D < 25 nmol/L (10 ng/dL). Association between mortality and severe vitamin D deficiency was examined. Data was analyzed by SPSS 24.0. Results: Out of 140 patients, 82 (58.57%) were males while 58 (41.43%) were females with mean age 42.46±14.73 years. Severe vitamin D deficiency was observed in 60 (42.86%) patients. Mortality found in 22 (15.71%) patients. Patients with severe vitamin D deficiency had high rate of mortality 16 (26.67%) as compared to patients with no vitamin D deficiency 6 (7.5%), a significant association was observed between severe vitamin D deficiency and mortality in patients with covid-19 disease with p-value