The influence of thiotriazoline on the indicators of nitric oxide under the condition of experimental contact dermatitis and experimental pneumonia

Regeda-Furdychko M. M. The influence of thiotriazoline on the indicators of nitric oxide under the condition of experimental contact dermatitis and experimental pneumonia. Journal of Education, Health and Sport. 2020;10(2):35-40. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.02.004 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.02.004 https://zenodo.org/record/3637411 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.01.2020. Revised: 25.01.2020. Accepted: 04.02.2020. The influence of thiotriazoline on the indicators of nitric oxide under the condition of experimental contact dermatitis and experimental pneumonia M. M. Regeda-Furdychko Lviv Medical Institute Abstract As a result of the conducted researches it is established that with the development of experimental contact dermatitis and experimental pneumonia there is an increase in the level of stable metabolites of nitric oxide, increase of activity of total NO synthase and, at the same time, inhibition of L-arginine activity in the blood, thus these indicators were most expressed on the late stages of her forming of combine pathology(18 th day). The use of thiotriazoline in curative aims stipulated the decline of stable NO metabolites on 31.9% (p≤0.05), NOS in blood on 26.6% (р1≤0.05) and increase of content L-arginine on 34.5% (р1≤0.05) at experimental contact dermatitis and experimental pneumonia as compared to the group of animals that did not yield to influence of this preparation. Key words: contact dermatitis; pneumonia; nitric oxide; thiotriazoline