QUINOLONES AS ANTIMICROBIAL AGENTS A REVIEW

Quinolones are synthetic antibacterial agents used in the treatment of a variety of bacterial infections initially, quinolones were mostly used in the treatment of Gram-negative infections, but they were later modified in order to improve their pharmacokinetic properties and extend their antibacterial spectrum, becoming effective against a wide variety of Gram-negative and Gram-positive pathogens. They have a relatively simple nucleus, and structural modifications are quite easy. Consequent to their broad spectrum of antimicrobial effect and safety profile, there was significant hope and anticipation that this class of antibiotics would find an imperative place in therapeutics. In this paper an attempt is made to review prospects of different classes of quinolone antibacterials only for the purpose of comparison. Keywords: Fluoroquinolones; Structural activity relationship; Resistance