First release of TRISTAN-rat repository to accompany the manuscript "Use of physiologically based pharmacokinetic and tracer kinetic models for prospective prediction and quantification of hepatic transporters drug-drug interaction via in vivo imaging in rats" by Nicola Melillo, Daniel Scotcher, J. Gerry Kenna, Claudia Green, Catherine D. G. Hines, Iina Laitinen, Paul D. Hockings, Kayode Ogungbenro, Ebony R. Gunwhy, Steven Sourbron, John C. Waterton, Gunnar Schuetz, and Aleksandra Galetin (referred to as the 'Six Test Compounds' study). Accompanying datasets for these scripts may be found at Rat gadoxetate MRI signal dataset for the IMI-WP2-TRISTAN Six Test Compounds study | Zenodo.If you use this software, please cite it using the metadat...
Drug distribution from blood to tissues, where pharmacological and/or toxic effects occur, often inv...
Investigation of pharmacokinetic/pharmacodynamic (PK/PD) rela-tionships for inhaled drugs is challen...
Putative in vitro-in vivo correlations of pharmacokinetic (PK) parameters are regarded as a prerequi...
First release of TRISTAN-rat repository to accompany the manuscript "Use of physiologically based ph...
Dataset to accompany the manuscript "Use of In Vivo Imaging and Physiologically-Based Kinetic Modell...
Drug-induced liver injury (DILI) is a leading cause of acute liver failure and transplantation. DILI...
Preclinical positron emission tomography studies are important to follow disease progression and dev...
Tyrosine kinase inhibitors are small molecules, orally available, well-tolerated and globally approv...
Preclinical positron emission tomography studies are important to follow disease progression and dev...
Drug-induced liver injury (Dili) is a leading cause of acute liver failure and transplantation. Dili...
Contains fulltext : 65625_phenthset.pdf (publisher's version ) (Open Access)RU Rad...
The histamine H3 receptor has been considered as a target for the treatment of various central nervo...
(A) Model. Gadoxetate, a gadolinium ion (Gd3+)-containing MRI-contrast agent, is taken up by hepatoc...
Drug-induced liver injury (DILI) is a clinically important adverse drug reaction, which prevents the...
We investigated the comparability of pharmacodynamic parameters for the occupancy of serotonin trans...
Drug distribution from blood to tissues, where pharmacological and/or toxic effects occur, often inv...
Investigation of pharmacokinetic/pharmacodynamic (PK/PD) rela-tionships for inhaled drugs is challen...
Putative in vitro-in vivo correlations of pharmacokinetic (PK) parameters are regarded as a prerequi...
First release of TRISTAN-rat repository to accompany the manuscript "Use of physiologically based ph...
Dataset to accompany the manuscript "Use of In Vivo Imaging and Physiologically-Based Kinetic Modell...
Drug-induced liver injury (DILI) is a leading cause of acute liver failure and transplantation. DILI...
Preclinical positron emission tomography studies are important to follow disease progression and dev...
Tyrosine kinase inhibitors are small molecules, orally available, well-tolerated and globally approv...
Preclinical positron emission tomography studies are important to follow disease progression and dev...
Drug-induced liver injury (Dili) is a leading cause of acute liver failure and transplantation. Dili...
Contains fulltext : 65625_phenthset.pdf (publisher's version ) (Open Access)RU Rad...
The histamine H3 receptor has been considered as a target for the treatment of various central nervo...
(A) Model. Gadoxetate, a gadolinium ion (Gd3+)-containing MRI-contrast agent, is taken up by hepatoc...
Drug-induced liver injury (DILI) is a clinically important adverse drug reaction, which prevents the...
We investigated the comparability of pharmacodynamic parameters for the occupancy of serotonin trans...
Drug distribution from blood to tissues, where pharmacological and/or toxic effects occur, often inv...
Investigation of pharmacokinetic/pharmacodynamic (PK/PD) rela-tionships for inhaled drugs is challen...
Putative in vitro-in vivo correlations of pharmacokinetic (PK) parameters are regarded as a prerequi...