COMPARISON OF THE MEAN BLOOD LOSS WITH SUBLINGUAL MISOPROSTOL VERSUS INTRAVENOUS OXYTOCIN IN LOW-RISK FEMALES UNDERGOING NORMAL VAGINAL DELIVERY

Background: Oxytocin and Misoprostol are considered to be the two most effective drugs in preventing PPH. But contradiction in literature was observed. So to confirm whether misoprostol is more effective than oxytocin for prevention of PPH, we conducted this study. Objective: To compare the mean blood loss with sublingual misoprostol versus intravenous oxytocin in low-risk females undergoing normal vaginal delivery Material & Methods: This randomized control trial was conducted at Unit IV, Department of Obstetrics and Gynecology, Lady Aitchison Hospital, Lahore. The duration of the study was six months from July 2016 to December 2016. The non-probability purposive sampling technique was used. The patients were randomly divided into two groups by using lottery method. The patients in group M received misoprostol 400µg sublingually and patients in group O, 20 units of oxytocin immediately after delivery of the baby. No Additional Oxytocin injection was given. Uterine massage was done if obstetrician noticed poor uterine contractions. Blood loss was estimated separately by measuring the blood in the kidney tray. Results: In this study the mean age of the patients was 29.33±7.06 years with mean gestational age of 38.74±1.22 weeks. The mean value of total blood loss of the patients was 429.97±135.06ml. In this study the value of total mean blood loss in misoprostol group was 356.29±84.89 ml and the mean value of total blood loss in oxytocin group was 503.66±135.98 ml. Statistically there is highly significant difference was found between the study groups and total blood loss of the patients i.e. pvalue=0.000 Conclusion: Our study results concluded that misoprostol showed more effective and satisfactory results as compared to intravenous oxytocin in low-risk females undergoing normal vaginal delivery. Keywords: Blood Loss, Sublingual Misoprostol, Intravenous Oxytocin, Vaginal Deliver