A REVIEW ON SULFONAMIDES

Sulfonamide drugs were the first antimicrobial drugs. The first sulfonamide was trade named Prontosil, which is a prodrug Prontosil, the first commercially available antibacterial with a relatively broad effect The sulphonamides or sulfa drugs competitively inhibit folic acid synthesis in micro-organisms and subsequently inhibit multiplication of bacteria but do not actively kill them. They have been used against most gram-positive and many gram-negative bacteria, some fungi, and certain protozoa. Keywords-SAR of sulfonamide