Role of Oxidative Strees and Antioxidants in Obese and non-obese womans with Polycystic Ovary Syndrome

The study was conducted on (90) blood samples, 60 samples from patients with (PCOS) and 30 of them were healthy women. Blood samples were collected from women attending outpatient clinics in Kirkuk Governorate, after their diagnosis. By obstetrics and gynecologists for the period from 11/20/2021 to 25/2/2022, as their ages ranged between (17-42) years, and they were divided into three groups depending on the body mass index (BMI), the first group (30) samples for patients with (PCOS) who are obese with BMI of more than 30 kg/m2 , and second group (30) samples for ladies without obesity who have polycystic ovary syndrome with a BMI of less than 25 kg / m2 and the third group (30) samples of non-infected women with a BMI of more than 30 kg / m2 as a control group. The study included the measurement of antioxidants, including non-enzymatic antioxidants It includes (glutathione, uric acid, and bilirubin), as well as measuring the concentration of malondialdehyde in obese, and without obesity (PCOS). The findings of this researh show following: * Increase that is statistically significant (P ≤0.01) in the concentration malondialdehyde when comparing obese women with PCOS with control, and increase that is statistically significant (P ≤0.05) when comparing between PCOS-afflicted obese and non-obese women * A notable reduction in the p-valu (P≤0.01) in the (bilirubin and glutathione) of concentration when comparing obese PCOS patients with control, a notable reduction and at the level of probability (P≤0.01) in the concentration of bilirubin and (P≤0.05) in the concentration of glutathione at Comparing obese women with PCOS to non-obese patients. * A notable reduction (P≤0.05) in the total capacity of antioxidants in obese women with PCOS compared with the control group, the results showed decrease that is statistically significant (P ≤0.01) when comparing the concentration of the total capacity of antioxidants between women Obese and non-obese patients. * A non-significant differences in uric acid concentration when comparing women with PCOS with control, and the results showed a increase that is statistically significant (P ≤0.05) when comparing women with PCOS who are obese with those who are not obese