Development Of Anti Inflammatory and Antimicrobial Silver Nanoparticles Coated Suture Materials

Background: Sutures are biomechanical devices used in oral surgery to avoid or limit the exposure of those parts exposed to saliva from bacterial colonization. Nanotechnology witnessed tremendous growth and became an integral part of medical sciences because of its wide range of application in different principles of diagnosis and treatment of various diseases. There has been an expeditious advance in medicines and biomaterial in the recent years. Nanomedicine aids in prevention, diagnosis, monitoring and treatment of the diseases. Aim: The aim of the current study was to synthesize biogenic silver nanoparticles using Solanum nigrumand Indigofera tinctoria as reducing agents and assess the antimicrobial, anti-inflammatory and the cytotoxic properties of the biogenic silver nanoparticles. Further the study also aims to analyse the application of biogenic silver nanoparticles coated on surgical sutures. Materials and Methods: In this report, we used the extract of Solanum nigrum and Indigofera tinctoria to synthesize silver nanoparticles and were characterized using UV-visible spectrophotometer, SEM and TEM. These nanoparticles were subjected to anti-inflammatory, Anti-microbial and and cytotoxic assays. Further these nanoparticles synthesized were coated on surgical silk sutures and subjected to antimicrobial assay. Results: The formed nanoparticles inherited important antibacterial properties against Pseudomonas sp, streptococcus mutan and staphylococcus aureus. They also possess anti inflammatory activity and also prove to be biocompatible. Conclusion: This break through in the field of surgical biomaterial may help reduce the toxic effects of pathogenic organisms while representing an environmentally friendly material which would not only be economically efficient but also proves to be a material with minimal risk to mankind and the environment