The simultaneous non-aqueous potentiometric determination of binary mixture of pharmaceutically potent drugs

Department of Chemistry, Shri Radhakisan Laxminarayan Toshniwal College of Science, Akola-444 001, Maharashtra, India E-mail : pradip222091@yahoo.co.in Manuscript received online 17 January 2013, accepted 24 August 2013 The simultaneous non-aqueous potentiometric determination of binary mixture of pharmaceutically potent drugs by using isopropyl alcohol as the solvent and KOH in isopropyl alcohol as the titrant has been carried out. The two acidic drugs nimesulide-paracetamol and ibuprofen-paracetamol were determined simultaneously in their binary mixtures by non-aqueous differentiating potentiometric titrations. These drug combinations are widely used in medicines. The titrations were carried out using glass and calomel electrode pair. The method was found to be convenient for assay of double component tablets and results obtained are comparable with those obtained by I.P. method