Vitamin D Deficiency and its Relation to Lipid Profile

Background Vitamin D deficiency is considered as a major public health problem all over the world. Vitamin D acts as a hormone with multi-functions. The main source of vitamin D is solar UV radiation, which converts 7-dehydrocholesterol to pro-vitamin D which is modified to vitamin D given normal skin temperature. Vitamin D deficiency is a common disorder presents in all ages and in both genders. Vitamin D plays an important role in modulating the immune response to infections and reduction inflammatory response. Vitamin D deficiency has a genetic predisposition. There is a correlation between low 25-hydroxyvitamin D levels and dyslipidemia, so correction of vitamin D deficiency is important for treating disturbance in lipid profile. Repletion of 25-hydroxy vitamin D levels raised serum calcium level and decrease parathyroid hormone levels. Materials : The study was carried out in a clinical Lab Al-Safowa in Cairo , Egypt on blood samples taken from 39 female patients, in the period from October 2019 to May 2020. Patients aged between (25-45) years old, all suffering from vitamin D deficiency indicated by unclear bony pain . The blood samples were estimated for lipid profile by fasting serum samples using colorimetric method and vitamin D estimation by ELIZA. The results were analyzed using SPSS (T-Test).Results: There were significant correlation between vitamin D deficiency and hypercholesterolemia and increase LDL levels(P 0.05). Conclusions: Vitamin D deficiency is correlated with increase in LDL , cholesterol. Recommendation: It is important to correct vitamin D deficiency to treat hyperlipidemia and so protection from cardiovascular diseases