A New Cohesive High-Concentrated Hyaluronic Acid Gel Filler: Correlation between Rheologic Properties and Clinical Indications

Background: Differences among the Available Hyaluronic (HA) gels are relevant to clinical practice as the HA physicochemical characteristics guide cosmetic indications. Besides, the literature still needs more information about the correlation between the HA gel’s behavior through their rheologic parameters and clinical indications. Objectives: We aim to evaluate the rheological properties of three gels with high concentrations of HA, e.p.t.q. S100®, S300®, and S500® (Jetema®) and extrapolate the results to their behavior after applied to the skin. Methods: To correlate the physicochemical properties of e.p.t.q. gels to their possible clinical indications, three presentations of these gels were evaluated. The storage modulus (G’), loss modulus (G”), tan δ, complex modulus, viscosity, and cohesiveness were measured by rheology. Results: The gels were non-Newtonian fluid with pseudoplastic behavior. All of them presented as elastic liquids (G’>G”). The S500 gel showed the highest G’ and complex modulus. S100 gel showed the highest tan δ and cohesiveness. S300 gel showed intermediary properties with tan δ and viscosity similar to the S500. Discussion: Due to the high G’ and low tan δ, S500 gel is indicated for facial structuring and lifting. On the opposite, low G’ and high tan δ of S100 gel signal for refinement. The intermediate values of the S300 point it to lift or refinement. Conclusions: According to the rheological results, we can assume that each gel has a specific indication, and the combination of S500, S300, and S100 enables a global facial treatmen