Evaluation of the influence of Chloride Sodium rape on the external application on the structural and functional condition of rats kidney on development

Gushcha S. G., Nasibullin B. A., Zukow W., Savitskyi I. V., Volyanska V. S. Evaluation of the influence of Chloride Sodium rape on the external application on the structural and functional condition of rats kidney on development. Journal of Education, Health and Sport. 2019;9(10):109-120. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3491052 http://ojs.ukw.edu.pl/index.php/johs/article/view/7587 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 25.09.2019. Revised: 30.09.2019. Accepted: 15.10.2019. EVALUATION OF THE INFLUENCE OF CHLORIDE SODIUM RAPE ON THE EXTERNAL APPLICATION ON THE STRUCTURAL AND FUNCTIONAL CONDITION OF RATS KIDNEY ON DEVELOPMENT S. G. Gushcha1, B. A. Nasibullin1, W. Zukow2, I. V. Savitskyi3, V. S. Volyanska1 1State Institution «Ukrainian Research Institute of Medical Rehabilitation Therapy of Ministry of Health of Ukraine», Odesa, Ukraine 2Nicolaus Copernicus University, Torun, Poland 3Odesa national medical university, Odesa, Ukraine Abstract Much attention has been paid to the study of the numerous effects of chronic stress and the methods of their correction, but some questions remain unanswered. Goal. To investigate the effect of highly mineralized sodium chloride mineral water (brine) on the structural and functional state of rat kidneys with experimental distress. White female rats weighing 180 - 220 g were ranked into three groups: group I intact rats (control), group II rats with a distress model (duration 30 days); group III - rats with a model of distress, who from 15 to 30 day of experiment received a course of external procedures with rapes. In group II rats, the development of distress caused dystrophic changes in the kidneys, which led to inhibition of their urinary, ion-regulating and excretory functions. To correct the manifestations of distress rats received a course of external procedures with brine (5 procedures for 2 hours a day). Renal function restored: GFR exceeds group I data by 30%, resulting in complete recovery of the diuresis. Urea excretion is restored, and creatinine excretion exceeds the control level by 30% (p