Synthesis and antimicrobial screening of some new N3-substituted derivatives of quinazolin-4(3H)-one

Padmabhushan Dr. Vasantraodada Patil Mahavidyalaya, Tasgaon-416 312, Dist. Sangli, Maharashtra, India E-mail : sanyujapatil@yahoo.com Department of Chemistry, Shivaji University, Kolhapur-416 004, Maharashtra, India Manuscript received online 31 December 2012, revised 15 February 2013, accepted 05 March 2013 3-(2-Oxopropyl)quinazolin-4(3H)-one (1) when reacts with phenyl hydrazine, 2,4-dinitro phenyl hydrazine gave the corresponding hydrazones (2a,b). Also 1 on treatment with malononitrile forms intermediate dicyano compound 3 which again on reaction with hydrazine hydrate gave cyanohydrazine 4. When the synthesized compounds were screened for their antimicrobial activity, were found to be active against certain Gram +ve and –ve bacterial and fungal species. The excellent results showed by some of them. The synthesized compounds were characterized by the IR and 1H NMR spectral data along with elemental analysis