A COHORT SERIES TO DOCUMENT ANY POSSIBLE CORRELATION BETWEEN MISCARRIAGES DURING FIRST TRIMESTER WITH AN ONSET OF PRETERM & PPROM DELIVERIES

Objective: In this research, we aimed to document the correlation of threatened miscarriage during the first trimester with Preterm and PPROM deliveries. Methodology: We completed this cohort series in Gynecology and Obstetrics Department of Jinnah Hospital, Lahore in the timeframe of February to December 2017. This research included a total of one hundred patients equally divided into two groups having fifty in each group. Group – I and Group – II respectively included the first trimester, bleeding and booked women before the completion of fourteen gestational weeks. The gestational age was estimated on the basis of fetal heart activity and scan; whereas, Group – II all booked, without bleeding and first trimester women having fetal heart activity. The age of the women included in Group – II was in the bracket of 20 years to 35 years having a maximum parity of five. We did not include any female with a twin pregnancy, distorting of uterine cavity large leiomyomata, congenital uterine anomaly, chronic diabetes history or hypertension, gestational diabetes, vaginal spotting, open cervix outcomes, polyhydramnios, preterm labour history and PPROM. All the females were regularly followed from the first day of the appointment to delivery. We also examined the demographic data including gestational and maternal age. First-trimester miscarriage refers to a miscarriage before the completion of fourteen gestational weeks. Preterm labour refers to a birth before the completion of thirty-seven gestational weeks. PPROM refers to a fetal membranes rupture before the completion of thirty-seven gestational weeks. We followed the patients till delivery in both the groups for an absence or presence of Preterm and PPROM delivery. Results: We compared the association of threatened miscarriage during the first trimester with PPROM and preterm deliveries in Group – I & II. Group – I shows 26 females (52%); whereas, Group – II shows 9 females (18%) with a relative risk of (2.889) that is (> 2). We also compared the onset of PPROM deliveries association with threatened miscarriage during the first trimester. There was a significant variation between the outcomes of both groups as Group – I had 9 cases (18%) and Group – II had 6 cases (12%) with a relative risk factor of (2.25). Conclusion: The correlation of threatened miscarriage during the first trimester with Preterm and PPROM deliveries was higher than the patients not in the first trimester. Keywords: Trimester, Miscarriage, Preterm, PPROM, Relative Risk, Bleeding, Parity and Delivery