A REVIEW ON INNOVATIVE AND NOVEL STRATEGY-FLOATING MICROSPONGES

Gastroretentive drug delivery system is a novel method for making the control release drug delivery system. Floating or Gastroretentive drug delivery system holds the advantage of both oral delivery and controlled delivery. Many control release formulations are developed with this method. Most useable and efficient technique is floating microsponges. The Microsponges Delivery System is an original polymeric system consisting of porous microspheres. They are tiny sponge like spherical particles. Microsponges having a countless of interconnected size ranging voids of particle from 5-150 µm. This Microsponges floats on the aqueous fluid of stomach and Releases the medicament for prolonged period of time. For those drugs whose half life is too short. Thus, beneficial for increasing their half life and also increase their bioavailability. These microsponges have more surface area so remain float on an aqueous media. Microsponges are prepared by several methods utilizing quasi emulsion system diffusion or by liquid– liquid suspension polymerization system. Thus this is a useful method. Key Words: FDDS, Microsponges, Quasi-emulsion solvent diffusion method, Liquid- liquid suspension polymerization , Gastrointestinal system