PANCREOPROTECTIVE AND ANTI-DIABETIC ACTIVITY OF PHYLLANTHUS AMARUS SEEDS METHANOLIC EXTRACTS IN ALLOXON INDUCED DIABETIC RATS

ABSTRACT A Pancreoprotective and Anti-Diabetic activity of Alloxon induced Pancreas were reversed by using methanolic extracts of 150 mg/kg and 250 mg/kg in rats. Seeds of Phyllanthus amarus extracts were found to have Pancreoprotective properties in rats with Alloxon induced Panceatic damage as judged from histopathalogical changes and Anti hyperglycemic activity of methanolic extracts of 150mg/kg and 250mg/kg in Diabetic rats. The methanolic extracts showed improvement in different parameters associated with diabetes like body weight, lipid profile and biochemical parameters. Methanolic extracts also showed improvement in regenation of β-cells of pancreas in Diabetic rats. Histopathological studies strengthen the healing of Pancreas by methanolic extracts of Phyllanthus amarus seeds showing panceoprotective and Anti-Diabetic activity. KEYWORDS: Phyllanthus amarus, Diabetes mellitus, Pancreoprotective, Alloxon induced and Methanolic extracts