Evaluation of the influence of thiotriazoline on the cytokine status disturbances in the blood serum under the condition of experimental contact dermatitis and experimental pneumonia

Regeda-Furdychko M. M. Evaluation of the influence of thiotriazoline on the cytokine status disturbances in the blood serum under the condition of experimental contact dermatitis and experimental pneumonia. Journal of Education, Health and Sport. 2020;10(1):25-30. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.01.003 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.01.003 http://dx.doi.org/10.5281/zenodo.3608016 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 20.12.2019. Revised: 25.12.2019. Accepted: 14.01.2020. Evaluation of the influence of thiotriazoline on the cytokine status disturbances in the blood serum under the condition of experimental contact dermatitis and experimental pneumonia M. M. Regeda-Furdychko Lviv Medical Institute Abstract The aim of our research was to determine the character of the disturbances content level of pro-inflammatory interleukin-6, tumor necrosis factor-α and anti-inflammatory cytokine interleukin-10 (IL-10) in the serum of guinea pigs and estimation of thiotriazoline influence on the cytokine profile in the conditions of formation of combined pathology - experimental contact dermatitis and experimental pneumonia. It has been determined significant advantage of pro-inflammatory cytokine activity, which increasing according the development of the combined pathological process and, simultaneously, reducing the anti-inflammatory IL-10. It has been detected corrective action of thiotriazoline on the investigated indices of cytokine profile. Key words: contact dermatitis; pneumonia; cytokines; thiotriazoline