EFFECT OF MOUTH RINSING WITH SOLUTIONS CONTAINING DIFFERENT COMMERCIALLY AVAILABLE SUGAR SUBSTITUTES ON SALIVARY PH- AN IN VIVO RANDOMIZED CONTROLLED TRIAL.

Lead (Pb) is being currently used in various forms and is getting exposed to living system via different routes. To determine the ameliorative effect of flaxseed extract on biochemical changes due to lead poisoning in Swiss albino mice for thirty days, mice were assigned to four groups i.e. (i) control group (ii) mice treated with 10 mg/kg body weight of lead acetate orally (iii) mice given 100 mg/kg body weight of flaxseed extract orally (iv) flaxseed extract plus lead acetate treated group. Exposure to lead resulted in reduction in brain triglycerides and phospholipids concentrations. A non significant decline in cytochrome c oxidase (COX) activity was observed in lead acetate treated group. However, triglyceride and phospholipid alterations in brain induced by lead acetate were mitigated in mice co treated with flaxseed extract and also exhibited a significant increase in COX activity. These findings indicate that flaxseed has beneficial effects and it mitigates lead acetate induced neurotoxicity