TO STUDY ON ABRESHAM (BOMBYX MORI): COCOON, FORMULATION ON HYPERLIPIDEMIC PATIENTS

Background: The silk worm Bombyx mori is a domesticated insect, which feeds exclusively on mulberry leaves to produce raw silk in the form of cocoon. Commonly it is known as Abresham and possesses the antioxidant activity and rich flavonoid contents. Since the ancient times it has been used to treat cardiac ailments due to the lipid lowering properties attributed to it which are well documented. Objective: The objective to explore the potential of Bombyx mori cocoon formulation (khamira Abresham Hakim Arshad Wala) in the reduction of hyperlipidemia. Methodology: Fifty hyperlipidemic male and female patients were taken and their lipid profile (cholesterol , triglycerides, HDL, LDL) liver function test (bilirubin toal, bilirubin direct, SGPT, SGOT, alkaline phosphate) and renal function test (blood urea,serum creatinine) were studied before, and after six and twelve weeks of treatment with Bombyx mori cocoon formulation. After 6th and 12th week, all the parameters were studied to evaluate the mean difference in their values. Results: In lipid profile parameters there was decrease in cholesterol level (mg/dl) 197.36 ± 12.86 to 194.00 ± 17.60 after six and twelve weeks of treatment. There was decrease in triglycerides (mg/dl) 122.640 ± 23.4640 after the 6th week and little increase to 123.94 ± 17.50 after the 12th week of treatment. In the liver function test of total bilirubin (mg/dl) the value was decreased to 0.612 ± 0.1081and 0.56 ± 0.08 after 6th and 12th week. There was no change in the values of direct bilirubin before and after the treatment. The values of SGOT were also decreased to 26.90 ± 5.92 and 25.96±5.81mg/dl after the 6th and 12th week of treatment. In the renal function parameters the blood urea mean level was decreased to 34.740± 6.4581and 34.04± 6.43 after 6th and 12th week. Conclusion: By the utilization of Bombyx mori cocoon formulation a decrease in cholesterol, triglycerides, LDL, total bilirubin, SGPT, SGOT, an increase in blood urea, while no change in direct bilirubin was observed. Key Words: LDL, HDL, SGPT, SGOT, Cholesterol