A Prospective Study for Comparison of Dosimetric Analysis, Radiation Induced Toxicities and Response in Flattening Filter Versus Flattening Filter Free Beam in Oral Cavity Cancers

Aim: This study aimed to compare the response, dosimetric parameters and toxicities of IMRT with Flattening Filter(FF) photon beam and Flattening Filter Free(FFF)photon beam in Oral Cavity cancers. Material and Methods-This study was conducted as prospective observational study on total of 60 cases of oral cavity cancerat our institute during study period of 2 years. All 60 participants were randomly assigned into either of the two treatment group IMRT-FF and IMRT-FFF.Patients were followed and assessment of dosimetric parameters, response and toxicities grading was done. Results- Two groups were comparable with respect to baseline variables and tumor characteristics and treatment (p>0.05). Mean number of fractions, as well as dose to brainstem, spinal cord and parotid were significantly higher in FF group as compared to FFF group (p<0.05). The response rate following radiation was found to be significantly better in FFF group as compared to FF group (p<0.05). Skin toxicities were significantly higher in FFF group at 3 months (p<0.05) whereas parotid as well as oral cavity were significantly higher in FF group at 3 and 6 months (p