Clinical Profile and Outcome of Renal Transplant Patients with Covid 19

INTRODUCTION : COVID 19 a pandemic caused by SARS CoV 2 has caused a wide impact globally. Clinical spectrum of COVID 19 ranges widely including asymptomatic infection, mild upper respiratory tract infection, severe pneumonia, ARDS, MODS and even death. According to Centres for disease control and prevention(CDC) immune compromised patients including patients on immune suppression post organ transplantation are high risk for severe disease from infection with SARS CoV 2. MATERIALS AND METHODS: A study was conducted on 24 Post renal transplant patients infected with COVID 19 who were admitted in hospitals attached to BMCRI. History was taken, general and systemic examination was done. Patients’ demographic data, clinical history and examination, lab investigations and radiological investigations, treatment given were assessed. Patients were categorized into mild, moderate and severe illness and followed up daily until outcome. RESULTS: The study included 24Post renal transplant patients infected with COVID 19, of which2 were females and 22 males. Of which mean age was 43.83 with standard deviation of 12.67.9 patients had mild, 4 had moderate and 11patient had severe disease. Of all the patients 10 died and 14 discharged. 2 patients were asymptomatic, most common symptom was cough(19) followed by fever (18). In severe patients inflammatory markers were elevated, with mean values D dimer 1.67, CRP-183, LDH-616. Mean Urea(106.4) and creatinine (2.39)values were higher in severe disease. Higher D dimer and CRP associated with worse outcome. CONCLUSION: With increasing number of renal transplants being performed, immune compromised state as a risk factor of COVID 19 infection, understanding clinical profile of these patients is necessary. Our study reveals that higher inflammatory markers were significantly associated with severity of the COVID 19 disease and mortality