Introduction: Glaucoma is a common neurodegenerative disease for which current therapies are often insufficient. The purpose of our investigation was to determine whether Oligodendrocyte Precursor Cells (OPCs), a type of neural stem cell, can protect Retinal Ganglion Cells (RGCs) from glaucomatous damage in vivo. Methods: Intraocular pressure was chronically increased by trabecular laser treatment delivered unilaterally to adult rat eyes. OPCs were isolated in vitro and then transplanted intra vitreally either before, or concurrent with, injury induction. Results: Transplanted OPCs were found to survive within the eye for at least 12 weeks and to localize close to the RGCs. Moreover, OPCs significantly enhanced the survival of RGCs in the g...
A promising clinical application for stem and progenitor cell transplantation is in rescue therapy f...
This study explored the novel strategy of hypoxic preconditioning of Bone Marrow Mesenchymal Stem Ce...
Optic neuropathies, including glaucoma, are a group of neurodegenerative diseases, characterized by ...
Introduction: Glaucoma is a common neurodegenerative disease for which current therapies are often i...
BACKGROUND: Degeneration of retinal ganglion cells (RGCs) is a common occurrence in several eye dise...
© 2019 C. Randall Harrell et al. Glaucoma represents a group of progressive optic neuropathies chara...
BACKGROUND AIMS: Glaucoma is a leading cause of irreversible blindness involving loss of retinal ...
International audienceIntroduction : Glaucoma is a sight-threatening retinal neuropathy associated w...
poster abstractGlaucoma is a severe neurodegenerative disease of the retina, leading to eventual irr...
Development of new effective treatments for glaucomatous optic neuropathy is one of the most acute a...
We have previously characterized human neuronal progenitor cells (hNP) that can adopt a retinal gang...
Degeneration of retinal ganglion cells (RGCs) is a common occurrence in several eye diseases. This s...
Glaucoma is a group of irreversible blinding eye diseases characterized by the progressive loss of r...
A promising clinical application for stem and progenitor cell transplantation is in rescue therapy f...
International audienceBackground: Glaucoma is a blinding degenerative neuropathy in which the death ...
A promising clinical application for stem and progenitor cell transplantation is in rescue therapy f...
This study explored the novel strategy of hypoxic preconditioning of Bone Marrow Mesenchymal Stem Ce...
Optic neuropathies, including glaucoma, are a group of neurodegenerative diseases, characterized by ...
Introduction: Glaucoma is a common neurodegenerative disease for which current therapies are often i...
BACKGROUND: Degeneration of retinal ganglion cells (RGCs) is a common occurrence in several eye dise...
© 2019 C. Randall Harrell et al. Glaucoma represents a group of progressive optic neuropathies chara...
BACKGROUND AIMS: Glaucoma is a leading cause of irreversible blindness involving loss of retinal ...
International audienceIntroduction : Glaucoma is a sight-threatening retinal neuropathy associated w...
poster abstractGlaucoma is a severe neurodegenerative disease of the retina, leading to eventual irr...
Development of new effective treatments for glaucomatous optic neuropathy is one of the most acute a...
We have previously characterized human neuronal progenitor cells (hNP) that can adopt a retinal gang...
Degeneration of retinal ganglion cells (RGCs) is a common occurrence in several eye diseases. This s...
Glaucoma is a group of irreversible blinding eye diseases characterized by the progressive loss of r...
A promising clinical application for stem and progenitor cell transplantation is in rescue therapy f...
International audienceBackground: Glaucoma is a blinding degenerative neuropathy in which the death ...
A promising clinical application for stem and progenitor cell transplantation is in rescue therapy f...
This study explored the novel strategy of hypoxic preconditioning of Bone Marrow Mesenchymal Stem Ce...
Optic neuropathies, including glaucoma, are a group of neurodegenerative diseases, characterized by ...