A STUDY OF CREATINE PHOSPHOKINASE LEVELS IN CEREBROSPINAL FLUID AND SERUM IN PATIENTS OF PYOGENIC AND TUBERCULAR MENINGITIS

Background & objective: Creatine phosphokinase was measured serially in cerebrospinal fluid (CSF) and serum in forty patients, twenty each of pyogenic and tubercular meningitis. Twenty healthy cases act as control. The aim of the study is to find whether creatine phosphokinase levels has any diagnostic or prognostic significance in serum and C.S.F in cases of pyogenic and tubercular meningitis. Material and method: The enzymatic activity was measured serially on (1st, 3rd and 5th day) in cases of pyogenic meningitis and (1st, 3rd, 7th and 14th day) in tubercular meningitis. The clinical details including the level of consciousness, neurological deficit and mortality were correlated with the enzymatic activity and prognosis. Results: In pyogenic meningitis creatine phosphokinase activity in C.S.F. was raised on 1st day as comparison to tubercular meningitis it was on 3 rd day of admission and progressively dropped to significantly lower values with the recovery of the patient. Definite correlation was demonstrated between the enzyme activity in C.S.F. and level of consciousness, mortality in cases of tubercular and pyogenic meningitis. Conclusion: Creatine phosphokinase activity in cerebrospinal fluid has a diagnostic and prognostic value in patients of pyogenic and tubercular meningitis