Copy Number Variations in Adult Patients with Chronic Immune Thrombocytopenia

In this report we identified CNV regions unique to adult ITP patients. Despite several studies the genetic background of ITP is still unclear. There are studies on pediatric cases, describing several genes associated with the disease, but the data is still limited. Here, we aimed to identify regions that may play a role in the pathogenesis of adult ITP by SNP array technology. Our findings support the idea that ITP is not only clinically but also genetically heterogeneous and genetic modifiers play an important role in the development of the disease. We believe that this data will provide important bases for the future studies to enlighten ITP pathogenesis