High resolution wide field spiking simulations of mouse cortical hemisphere

Large-scale simulations of cortical models could help to shed light on the study of different brain states and cortical rhythms. In this talk, I will present high resolution wide-field spiking simulations of whole cortical hemisphere of a mouse at biological neural and synaptic density, reproducing the dynamics of Slow Wave Activity observed during anesthesia states. The model is obtained using parameters inferred from wide-field calcium imaging optical recordings acquired on anesthetized mice. Simulations are performed using two different spiking simulator engines (NEST and NEST GPU), and their outputs are analyzed using a tool suitable for the study of Slow Waves Activity. This methodology allows a direct comparison of outputs from different simulators, as well as between synthetic and experimentally recorded data, increasing the ability to refine and calibrate the model in terms of input parameters and biological plausibility