FORMULATION AND EVALUATION OF FOSINOPRIL FAST DISSOLVING TABLETS

The concept of formulating fast dissolving tablets using super disintegrants offers a suitable and practical approach of faster disintegration and dissolution characteristics. The formulations F1 to F9 Were prepared. Among the various method of preparation fast dissolving tablets were prepared by using super disintegrants like CCS, CP and SSG by direct compression. The formulations F1 to F3 are prepared with 10% concentration of CCS, CP and SSG. The formulations F4 to F6 are prepared with 15% concentration of CCS, CP and SSG. The formulations F7 to F9 are prepared with 20% concentration of CCS, CP and SSG. The prepared tablets of fosinopril were evaluated for precompression parameters like angle of repose, bulk density, tapped density, Carr’s index and postcompression parameters like the hardness, friability and weight variation, drug content, disintegration time, and in vitro dissolution studies. Among the various fast dissolving tablets of fosinopril F7 formulation shows maximum drug release in 1 min. Keywords: fosinopril, super disintegrants, bulk density, Carr’s index