ENHANCEMENT OF SOLUBILITY AND FORMULATION OF FAST DISSOLVING SUBLINGUAL WAFERS OF FLURBIPROFEN FOR EFFECTIVE TREATMENT OF DENTAL PAIN

The enhancement of dissolution rate and oral bioavailability of poorly soluble drugs remains one of the most challenging aspects of the drug development. Among the different methods of dissolution enhancement, Solid dispersion technology was found to be more successful with number of drugs. Solid dispersion of Flurbiprofen with PVP K-90 by physical mixture method were prepared. Further fast dissolving oral film of Flurbiprofen were conveniently formulated by solvent casting method. The In vitro dissolution studies showed that Flurbiprofen fast dissolving films formulation F3 showed maximum 98.78±0.25% over a period of 15min. Overall the results of the dissolution rate studies indicated greater dissolution rate of Flurbiprofen from fast dissolving oral film. Fast dissolving oral film containing Flurbiprofen were prepared using solvent casting method. Total six formulations were prepared using varying amount of Sodium Starch glycolate and Croscarmellose sodium. The prepared films were further evaluated for Thickness, Uniformity of Weight, Folding endurance, Disintegrating time, Tensile strength, Percentage Moisture Content, % Assay and In-vitro Release Studies. Percentage assay of different formulation was determined by UV-Vis Spectroscopy. The percentage assay of different formulation was in range of 97.14±0.41 to 99.45±0.36%