Carbon-carbon bond formation via palladium catalyzed reactions of organomercurials with acylhalides

  • P. G. More
  • N. V. Dalave
  • (MrS.) A. S. Lawand and A.M. Nalawade
Publication date
April 2007

Abstract

Department of Chemistry, Sola pur University, Solapur-413 255, Maharashtra, India Fax: 91-0217-2744770 Manuscript received 7 December 2006, accepted 27 February 2007 The palladium catalyzed acyldemetallation reactions of methyl mercury iodide provide a mild, selective and general method for the construction of new C-C bond i.e. for the synthesis of unsymmetrical ketone. The rection proceeds in acetone, in the presence of a nucleophilic catalyst (iodide ion), at room temperature. The catalytic cycle involved in the reaction consists of a sequence of oxidative addition, transmetallation and reductive elimination steps. The role played by the iodide ion as a nucleophilic catalyst is discussed

Extracted data

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