IMPACTS OF PREVENTIVE THERAPY ON THE RISK OF BREAST CANCER AMONG WOMEN WITH BENIGN BREAST DISEASE

Particular histologic kinds of BDD (benign breast disease) may elevate the risk of breast cancer. This study is based on the population-based data, case-control study of women aged 20 to 54 with newly diagnosed breast cancer and control subjects randomly selected from the general population. Pathologists’ panel classified the histologic findings of biopsy slides for 433 women with breast cancer and 261 control subjects, all of whom had a history of biopsy for BBD, according to the epithelial hyperplasia, atypia, and other histologic characteristics’ presence. The comparison is done with those women who had no experiences of breast biopsy, the BDD holding women without hyperplasia had an odds ratio of (95% confidence limit) 1.5, 1.3 to 1.9), and women with hyperplasia without atypia had an odds ratio of 1.8 (CL = 1.3, 2.4), and finally women with hyperplasia and atypia had an odds ratio of 2.6 (CL = 1.6, 4.1). Fibroadenoma is considered as an independent risk factor for breast cancer (according to odds ratio = 1.7; CL = 1.1, 2.5). These outcomes advised that women with BBD with epithelial hyperplasia either with or without atypia and women with fibroadenoma should be monitored carefully because of their elevated risk for breast cancer